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What is sodium butyrate?
Our genetic information is stored in genes. That information is used to make other products inside our cells, such as proteins. The transfer of information from genes to proteins is called gene expression. Sodium butyrate is a compound with many functions, including induction or repression of gene expression.
How can sodium butyrate help people living with PIGM-CDG?
PIGM-CDG happens because there is a defect in the transfer of information from the PIGM gene to make proteins. Sodium butyrate can help restore this process and increase PIGM gene expression. Sodium butyrate supplementation was tested in patient cells (in the lab) and in one patient who regained some capabilities and became seizure-free.
Publications in CDG are constantly growing. We have selected articles of special interest for you, see below. Not all are open access, thus if you wish to access the full information, please contact us at https://worldcdg.org/contact
